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1

Drug interactions with oral antidiabetic agents: pharmacokinetic mechanisms and clinical implications

Aleksi Tornio, Mikko Niemi, Pertti J. Neuvonen, Janne T. Backman

Journal:

Trends in Pharmacological Sciences

Year:

2012

Language:

english

File:

PDF, 585 KB

english, 2012

2

A Development of Tractor's Continuously Variable Transmission Based on Combined Planetary Gear Train (2nd Report, Design and Manufacture of Prototype Transmission and Experiments)

NAKAZAWA, Masaaki, KISHI, Satoshi, HORIUCHI, Tornio, WADA, Hitoshi, SANO, Shuichi, FUKADA, Shigeo

Journal:

TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series C

Year:

2006

File:

PDF, 4.17 MB

2006

3

Risk-benefit evaluation of nuclear power plant siting

J. Miettinen, I. Savolainen, P. Silvennoinen, E. Tornio, S. Vuori

Journal:

Annals of Nuclear Energy

Year:

1976

Language:

english

File:

PDF, 906 KB

english, 1976

4

Grapefruit Juice Inhibits the Metabolic Activation of Clopidogrel

Holmberg, M T, Tornio, A, Neuvonen, M, Neuvonen, P J, Backman, J T, Niemi, M

Journal:

Clinical Pharmacology & Therapeutics

Year:

2014

Language:

english

File:

PDF, 456 KB

english, 2014

5

Formation Mechanism of Interfacial Crud in Solvent Cleanup Process for Fuel Reprocessing

NAKAMURA, Tomotaka, FUKASAWA, Tetsuo, SASAHIRA, Akira, OZAWA, Masaki, TAMURA, Nobuhiko, KAWATA, Tornio

Journal:

Journal of Nuclear Science and Technology

Year:

1991

Language:

english

File:

PDF, 186 KB

english, 1991

6

Grapefruit juice markedly increases the plasma concentrations and antiplatelet effects of ticagrelor in healthy subjects

Holmberg, Mikko T., Tornio, Aleksi, Joutsi-Korhonen, Lotta, Neuvonen, Mikko, Neuvonen, Pertti J., Lassila, Riitta, Niemi, Mikko, Backman, Janne T.

Journal:

British Journal of Clinical Pharmacology

Year:

2013

Language:

english

File:

PDF, 893 KB

english, 2013

7

Critical Micelle Concentrations and Solubilization Powers of Sucrose Fatty Acid Esters

Baba, Tornio, Bushita, Takeshi

Journal:

The Journal of the Society of Chemical Industry Japan

Year:

1964

File:

PDF, 1.24 MB

1964

8

Association Between Psychosocial Problems and Unhealthy Health Behavior Patterns Among Finnish Adolescents

Marttila-Tornio, Kaisa, Ruotsalainen, Heidi, Miettunen, Jouko, MÃ¤nnikkÃ¶, Niko, KÃ¤Ã¤riÃ¤inen, Maria

Journal:

Child Psychiatry & Human Development

Year:

2020

Language:

english

File:

PDF, 513 KB

english, 2020

9

Febuxostat, But Not Allopurinol, Markedly Raises the Plasma Concentrations of the Breast Cancer Resistance Protein Substrate Rosuvastatin

Lehtisalo, Minna, Keskitalo, Jenni E., Tornio, Aleksi, LapattoâReiniluoto, Outi, Deng, Feng, Jaatinen, Taina, ViinamÃ¤ki, Jenni, Neuvonen, Mikko, Backman, Janne T., Niemi, Mikko

Journal:

Clinical and Translational Science

Year:

2020

File:

PDF, 610 KB

2020

10

The structure of diphenazithionin, a novel antioxidant from Streptomyces griseus ISP 5236

Yoshiko Hosoya, Hayamitsu Adachi, Hikara Nakamura, Yoshio Nishimura, Hiroshi Naganawa, Yoshiro Okami, Tornio Takeuchi

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 152 KB

english, 1996

11

Itraconazole, gemfibrozil and their combination markedly raise the plasma concentrations of loperamide

Mikko Niemi, Aleksi Tornio, Marja K. Pasanen, Hanna Fredrikson, Pertti J. Neuvonen, Janne T. Backman

Journal:

European Journal of Clinical Pharmacology

Year:

2006

Language:

english

File:

PDF, 299 KB

english, 2006

12

The CYP2C8 inhibitor gemfibrozil does not increase the plasma concentrations of zopiclone

Aleksi Tornio, Pertti J. Neuvonen, Janne T. Backman

Journal:

European Journal of Clinical Pharmacology

Year:

2006

Language:

english

File:

PDF, 191 KB

english, 2006

13

Stereoselective interaction between the CYP2C8 inhibitor gemfibrozil and racemic ibuprofen

Aleksi Tornio, Mikko Niemi, Pertti J. Neuvonen, Janne T. Backman

Journal:

European Journal of Clinical Pharmacology

Year:

2007

Language:

english

File:

PDF, 185 KB

english, 2007

14

Comparison of 3-Hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors (Statins) as Inhibitors of Cytochrome P450 2C8

Aleksi Tornio, Marja K. Pasanen, Jouko Laitila, Pertti J. Neuvonen, Janne T. Backman

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2005

Language:

english

File:

PDF, 73 KB

english, 2005

15

The Effect of Gemfibrozil on Repaglinide Pharmacokinetics Persists for at Least 12 h After the Dose: Evidence for Mechanism-based Inhibition of CYP2C8 In Vivo

Tornio, A, Niemi, M, Neuvonen, M, Laitila, J, Kalliokoski, A, Neuvonen, PJ, Backman, JT

Journal:

Clinical Pharmacology & Therapeutics

Year:

2008

Language:

english

File:

PDF, 331 KB

english, 2008

16

Variational Bayesian learning of nonlinear hidden state-space models for model predictive control

Tapani Raiko, Matti Tornio

Journal:

Year:

2009

Language:

english

File:

PDF, 309 KB

english, 2009

17

Keratinocyte growth factor in the promotion of human chorionic gonadotropin production in human choriocarcinoma cells

Fuminori Taniguchi, Tasuku Harada, Masayuki Ito, Souichi Yoshida, Tornio Iwabe, Masahiro Tanikawa, Naoki Terakawa

Journal:

American Journal of Obstetrics and Gynecology

Year:

2000

Language:

english

File:

PDF, 1.14 MB

english, 2000

18

Oc030—Gemfibrozil Impairs Imatinib Absorption And Inhibits The Cyp2c8-Mediated Formation Of Its Main Metabolite In Healthy Volunteers

Filppula, A.M., Tornio, A., Niemi, M., Neuvonen, P.J., Backman, J.T.

Journal:

Clinical Therapeutics

Year:

2013

Language:

english

File:

PDF, 81 KB

english, 2013

19

Gemfibrozil Impairs Imatinib Absorption and Inhibits the CYP2C8-Mediated Formation of Its Main Metabolite

Filppula, A M, Tornio, A, Niemi, M, Neuvonen, P J, Backman, J T

Journal:

Clinical Pharmacology & Therapeutics

Year:

2013

Language:

english

File:

PDF, 671 KB

english, 2013

20

RELATION BETWEEN MINIMUM PERCEPTIBLE WIRE AND COMBINATION OF RADIATION SOURCE AND X-RAY FILM

SENDA, Tornio, HIRAYAMA, Kazuo, YOKOYAMA, Keiji, NAKAMURA, Kazuo

Journal:

Nondestructive Testing Communications

Year:

1988

Language:

english

File:

PDF, 272 KB

english, 1988

21

CYP2C8 Activity Recovers within 96 Hours after Gemfibrozil Dosing: Estimation of CYP2C8 Half-Life Using Repaglinide as an in Vivo Probe

Backman, J. T., Honkalammi, J., Neuvonen, M., Kurkinen, K. J., Tornio, A., Niemi, M., Neuvonen, P. J.

Journal:

Drug Metabolism and Disposition

Year:

2009

Language:

english

File:

PDF, 910 KB

english, 2009

22

A Fail-Safe Reactor Safety System

TSUNODA, Tornio, GOTOH, Seiichiro, SUZUKI, Eiji

Journal:

Journal of Nuclear Science and Technology

Year:

1967

Language:

english

File:

PDF, 476 KB

english, 1967

23

[IEEE International Joint Conference on Neural Networks 2005 - Montreal, Que., Canada (31 July-4 Aug. 2005)] Proceedings. 2005 IEEE International Joint Conference on Neural Networks, 2005. - Learning nonlinear state-space models for control

Raiko, T., Tornio, M.

Year:

2005

Language:

english

File:

PDF, 2.22 MB

english, 2005

24

Trimethoprim and the CYP2C8*3 Allele Have Opposite Effects on the Pharmacokinetics of Pioglitazone

Tornio, A., Niemi, M., Neuvonen, P. J., Backman, J. T.

Journal:

Drug Metabolism and Disposition

Year:

2007

Language:

english

File:

PDF, 281 KB

english, 2007

25

Glucuronidation Converts Clopidogrel to a Strong Time-Dependent Inhibitor of CYP2C8: A Phase II Metabolite as a Perpetrator of Drug–Drug Interactions

Tornio, A, Filppula, A M, Kailari, O, Neuvonen, M, Nyrönen, T H, Tapaninen, T, Neuvonen, P J, Niemi, M, Backman, J T

Journal:

Clinical Pharmacology & Therapeutics

Year:

2014

Language:

english

File:

PDF, 2.34 MB

english, 2014

26

Effect of grapefruit juice on the bioactivation of prasugrel

Holmberg, Mikko T., Tornio, Aleksi, Hyvärinen, Hanna, Neuvonen, Mikko, Neuvonen, Pertti J., Backman, Janne T., Niemi, Mikko

Journal:

British Journal of Clinical Pharmacology

Year:

2015

Language:

english

File:

PDF, 884 KB

english, 2015

27

Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans

Tarkiainen, EK, Holmberg, MT, Tornio, A, Neuvonen, M, Neuvonen, PJ, Backman, JT, Niemi, M

Journal:

Clinical Pharmacology & Therapeutics

Year:

2015

Language:

english

File:

PDF, 990 KB

english, 2015

28

[IEEE 2014 Visual Communications and Image Processing (VCIP) - Valletta, Malta (2014.12.7-2014.12.10)] 2014 IEEE Visual Communications and Image Processing Conference - Face image processing by TV filter and super-resolution

Goto, Tornio, Hirano, Satoshi, Sakurai, Masaru

Year:

2014

Language:

english

File:

PDF, 859 KB

english, 2014

29

Carboxylesterase 1 C.428G>A single nucleotide variation reduces hydrolysis of clopidogrel and enalapril, but not that of Quinapril

Tarkiainen, E.K., Holmberg, M.T., Tornio, A., Neuvonen, M., Launiainen, T., Neuvonen, P.J., Backman, J.T., Niemi, M.

Journal:

Clinical Therapeutics

Year:

2015

Language:

english

File:

PDF, 52 KB

english, 2015

30

Electrolytic Extraction of Platinum Group Metals from Dissolver Solution of Purex Process

KOIZUMI, Kenji, OZAWA, Masaki, KAWATA, Tornio

Journal:

Journal of Nuclear Science and Technology

Year:

1993

Language:

english

File:

PDF, 181 KB

english, 1993

31

Clopidogrel Has No Clinically Meaningful Effect on the Pharmacokinetics of the Organic Anion Transporting Polypeptide 1B1 and Cytochrome P450 3A4 Substrate Simvastatin

Itkonen, M. K., Tornio, A., Neuvonen, M., Neuvonen, P. J., Niemi, M., Backman, J. T.

Journal:

Drug Metabolism and Disposition

Year:

2015

Language:

english

File:

PDF, 393 KB

english, 2015

32

Drug transporter protein-mediated drug interactions during pregnancy and offspring outcome; with special emphasis on SSRIs and second generation antipsychotics

Malm, Heli, Ellfolk, Maria, Tornio, Aleksi, Niemi, Mikko

Journal:

Reproductive Toxicology

Year:

2016

Language:

english

File:

PDF, 50 KB

english, 2016

33

Action of S -Carbamoyl and S -Thiocarbamoyl Derivatives of L -Cysteine on L -Amino Acid Oxidase

Kimura, Tornio, Esaki, Nobuyoshi, Tanaka, Hidehiko, Soda, Kenji

Journal:

Agricultural and Biological Chemistry

Year:

1984

Language:

english

File:

PDF, 514 KB

english, 1984

34

Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril

Tarkiainen, E. Katriina, Tornio, Aleksi, Holmberg, Mikko T., Launiainen, Terhi, Neuvonen, Pertti J., Backman, Janne T., Niemi, Mikko

Journal:

British Journal of Clinical Pharmacology

Year:

2015

Language:

english

File:

PDF, 995 KB

english, 2015

35

Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone

Itkonen, M. K., Tornio, A., Neuvonen, M., Neuvonen, P. J., Niemi, M., Backman, J. T.

Journal:

Drug Metabolism and Disposition

Year:

2016

Language:

english

File:

PDF, 1.32 MB

english, 2016

36

High Frequency of CYP2D6 Ultrarapid Metabolizer Genotype in the Finnish Population

Pietarinen, Paavo, Tornio, Aleksi, Niemi, Mikko

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2016

Language:

english

File:

PDF, 207 KB

english, 2016

37

SLCO1B1 polymorphism markedly affects the pharmacokinetics of lovastatin acid

Tornio, Aleksi, Vakkilainen, Juha, Neuvonen, Mikko, Backman, Janne T., Neuvonen, Pertti J., Niemi, Mikko

Journal:

Pharmacogenetics and Genomics

Year:

2015

Language:

english

File:

PDF, 180 KB

english, 2015

38

Purification and Characterization of Spirosomes in Lactobacillus brevis

Ueki, Yukihide, Masuda, Kuniyoshi, Kawata, Tornio

Journal:

Microbiology and Immunology

Year:

1982

Language:

english

File:

PDF, 1.70 MB

english, 1982

39

Role of gemfibrozil as an inhibitor of CYP2C8 and membrane transporters

Tornio, Aleksi, Neuvonen, Pertti J., Niemi, Mikko, Backman, Janne T.

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2016

Language:

english

File:

PDF, 924 KB

english, 2016

40

10.1252/kakoronbunshu.7.415

Nakajima, Satoshi, Takama, Norihiro, Shiroko, Katsuo, Umeda, Tornio

Journal:

KAGAKU KOGAKU RONBUNSHU

Year:

1981

File:

PDF, 1.13 MB

1981

41

10.1252/kakoronbunshu.7.77

Hirama, Toshimasa, Tomita, Minoru, Adachi, Tornio, Horio, Masayuki

Journal:

KAGAKU KOGAKU RONBUNSHU

Year:

1981

File:

PDF, 1.14 MB

1981

42

Spatial Correlation Measurements in Flow over a Rectangular Cube by Means of LDA and PIV.

NOMURA, Tomokazu, ISHIMA, Tsuneaki, OBOKATA, Tornio

Journal:

TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series B

Year:

2004

File:

PDF, 3.37 MB

2004

43

Influence of Occlusion Movement on Amount of Parotid Saliva

SUHARA, Rokuro, ONO, Kiyoshi, TAKIKAWA, Tornio, TANAKA, Masao

Journal:

The Journal of Nihon University School of Dentistry

Year:

1959

Language:

english

File:

PDF, 462 KB

english, 1959

44

Hydrogeology of the Nasu plain, Tochigi prefecture

SASAKI, Makoto, AJISAKA, Tornio, OKAMOTO, Akira

Journal:

Journal of Geography (Chigaku Zasshi)

Year:

1958

File:

PDF, 2.05 MB

1958

45

Auditory Cortical Response to Monaural Stimulation as Detected by Functional Magnetic Resonance Imaging

Suzuki, Mikio, Ogawa, Tornio, Kitano, Hiroya, Yazawa, Yoshiro, Kitajima, Kazutomo

Journal:

Nippon Jibiinkoka Gakkai Kaiho

Year:

2000

File:

PDF, 2.06 MB

2000

46

Effects of carboxylesterase 1 single nucleotide variations on the pharmacokinetics and pharmacydynamics of clopidogrel

Katriina Tarkiainen, E., Neuvonen, Mikko, Tornio, Aleksi, Holmberg, Mikko T., Itkonen, Matti, Neuvonen, Pertti J., Backman, Janne T., Niemi, Mikko

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2017

Language:

english

File:

PDF, 47 KB

english, 2017

47

Identification of novel genetic variants associated with membrane transporter, drug metabolizing enzyme and nuclear receptor gene expression in whole blood

Neuvonen, Mikko, Hirvensalo, Päivi, Tornio, Aleksi, Tarkiainen, Katriina, Paile-Hyvärinen, Maria, Tapaninen, Tuija, Backman, Janne T., Niemi, Mikko

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2017

Language:

english

File:

PDF, 48 KB

english, 2017

48

Glucuronidation of clopidogrel by human UGT enzymes: Major contributions by UGT2B7 and UGT2B17

Kahma, Helinä, Filppula, Anne M., Neuvonen, Mikko, Tornio, Aleksi, Tarkiainen, E. Katriina, Holmberg, Mikko T., Itkonen, Matti K., Finel, Moshe, Neuvonen, Pertti J., Niemi, Mikko, Backman, Janne T.

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2017

Language:

english

File:

PDF, 49 KB

english, 2017

49

Investigating Real-World Clopidogrel Pharmacogenetics in Stroke Using a Bioresource Linked to Electronic Medical Records

Tornio, Aleksi, Flynn, Rob, Morant, Steve, Velten, Elena, Palmer, Colin N.A., MacDonald, Thomas M., Doney, Alex S.F.

Journal:

Clinical Pharmacology & Therapeutics

Year:

2017

Language:

english

File:

PDF, 961 KB

english, 2017

50

Noise and Vibration Generated by Underground Railways

Betsui, Hitoshi, Suzuki, Tornio, Natori, Hyoichi, Terabe, Motoji

Journal:

Journal of Low Frequency Noise Vibration and Active Control

Year:

1982

Language:

english

File:

PDF, 769 KB

english, 1982

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